Home > 暂无记录 Signal Pathway > Neuronal Signalling

Neuronal Signalling


Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience is recognized as a branch of biology. 

A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the brain and spinal cord of the central nervous system (CNS), and of the ganglia of the peripheral nervous system (PNS).

All neurons are electrically excitable, maintaining voltage gradients across their membranes by means of metabolically driven ion pumps, which combine with ion channels embedded in the membrane to generate intracellular-versus-extracellular concentration differences of ions such as sodium, potassium, chloride, and calcium. Changes in the cross-membrane voltage can alter the function of voltage-dependent ion channels. If the voltage changes by a large enough amount, an all-or-none electrochemical pulse called an action potential is generated, which travels rapidly along the cell's axon, and activates synaptic connections with other cells when it arrives. 

  • Tasquinimod EY1756

    Tasquinimod(ABR-215050)是喹啉-3-甲酰胺利诺胺类似物,具有抗血管生成和抗肿瘤活性。

    More
  • CAY10603 EY1717

    CAY10603是HDAC6高效特异性抑制剂,IC50值为2 pM,对HDAC1、2、3、8、10的IC50值分别为271, 252, 0.42, 6851,和90.7nM。

    More
  • M344 EY1676

    M344是HDAC抑制剂,能在MCF-7细胞中诱导Puma和Bax基因的表达,以及凋亡形态学特征的出现。

    More
  • LAQ824 EY1389

    LAQ824 (Dacinostat)是新型HDAC抑制剂,IC50为32 nM,且激活p21启动子。

    More
  • PCI-24781 EY1368

    PCI-24781是一种新型的pan-HDAC抑制剂,靶向作用于HDAC1,Ki为7 nM,对HDACs 2, 3, 6,和10有适中的抑制性,但比作用于HDAC8选择性强40倍。

    More
  • Current page12, Total Pages15, Total Record72 First Prev 1011121314 Next Last Goto